What is Huperzine-A?

Huperzine-A is a naturally occurring compound that has been traditionally used for its cognitive-enhancing properties. It belongs to a class of substances known as alkaloids and is derived from the Huperzia serrata plant, commonly known as Chinese club moss.

Where does Huperzine-A come from?

Huperzine-A is derived from the Huperzia serrata plant, which is native to China, India, and parts of Southeast Asia. The plant has been used for centuries in traditional Chinese medicine for its various therapeutic properties.

What are the effects of Huperzine-A?


  • Enhanced memory and learning[2]
  • Increased alertness and mental clarity
  • Potential neuroprotective effects[1]


  • Improved sleep quality
  • Reduced muscle fatigue

How to use Huperzine-A?

Huperzine-A is typically available in tablet, capsule, or powder form. It can be taken as a dietary supplement for cognitive enhancement, improved sleep quality, or reduced muscle fatigue. To experience the desired effects, it is important to follow the recommended dosages and consult with a healthcare professional before starting any supplementation regimen.

How much Huperzine-A to use?

When trying out new supplements it is wise to start with a lower dose and–depending on the experienced effects–increase or decrease the dosage accordingly

The recommended dosages for Huperzine-A can vary depending on factors such as age, weight, and desired effects. However, common dosages include:

  • 50 mcg for cognitive enhancement
  • 100 mcg for sleep improvement
  • 200 mcg for reduced muscle fatigue

It is essential to start with the lowest effective dose and gradually increase it based on individual tolerance and desired effects.

What are the side effects of Huperzine-A?

While Huperzine-A is generally considered safe when taken in appropriate dosages, some individuals may experience side effects. Common side effects include:

  • Nausea
  • Diarrhea
  • Vomiting
  • Dizziness
  • Insomnia
  • Headache

If any of these side effects persist or worsen, it is important to discontinue use and consult a healthcare professional.

Interactions of Huperzine-A

Most nootropics are relatively safe to use on their own. Combining them with other substances may cause them to suddenly become dangerous or life-threatening.

Huperzine-A may interact with certain medications or other supplements, which could lead to adverse effects or reduced effectiveness. Some potential interactions include:

  • Anticholinergic drugs
  • Cholinesterase inhibitors
  • Beta-blockers
  • Calcium channel blockers


  1. [1] Wang, R., & Tang, X. C. (2005). Neuroprotective effects of huperzine A. Neurosignals, 14(1-2), 71-82.
  2. [2] Sun, Q. Q., Xu, S. S., Pan, J. L., Guo, H. M., & Cao, W. Q. (1999). Huperzine-A capsules enhance memory and learning performance in 34 pairs of matched adolescent students. Zhongguo yao li xue bao= Acta pharmacologica Sinica, 20(7), 601-603.
Other namesHupA, Qian Ceng Ta
EffectsSleep, Focus
Half-life12 hours (10 - 14)