What is Sulbutiamine?

Sulbutiamine is a synthetic derivative of vitamin B1 (thiamine), specifically designed to cross the blood-brain barrier more efficiently than thiamine. It was developed in Japan in the 1960s as a treatment for thiamine deficiency and related neurological symptoms. Sulbutiamine is often considered a nootropic or cognitive enhancer due to its potential positive effects on memory, focus, and mood.

Where does Sulbutiamine come from?

Sulbutiamine was initially synthesized in Japan as a response to widespread cases of beriberi, a disease caused by thiamine deficiency. It is a lipophilic molecule formed by the esterification of two thiamine molecules, which allows it to cross the blood-brain barrier more effectively and lead to increased levels of thiamine in the brain.

What are the effects of Sulbutiamine?


  • Enhances memory and learning
  • Increases focus and attention
  • Reduces anxiety and stress
  • Improves mood and motivation


  • Reduces fatigue
  • Improves energy levels

How to use Sulbutiamine?

Sulbutiamine is available in powder or capsule form and is typically taken orally. It can be consumed with or without food, but it is fat-soluble, so taking it with a meal containing dietary fat may improve absorption.

How much Sulbutiamine to use?

When trying out new supplements it is wise to start with a lower dose and–depending on the experienced effects–increase or decrease the dosage accordingly

Typically, the following dosages are recommended for Sulbutiamine:

  • 50 mg for a mild dose
  • 250 mg for a medium dose
  • 500 mg for a strong dose

It is crucial to start with a low dose and gradually increase it to assess individual tolerance and response. Consult a healthcare professional before starting any new supplement regimen.

What are the side effects of Sulbutiamine?

Sulbutiamine is generally well-tolerated, but some users may experience side effects such as headache, nausea, irritability, or insomnia. These side effects are usually mild and can be managed by adjusting the dosage or discontinuing use.

Interactions of Sulbutiamine

Most nootropics are relatively safe to use on their own. Combining them with other substances may cause them to suddenly become dangerous or life-threatening.

Although Sulbutiamine is considered relatively safe, it may interact with certain medications or other supplements. Always consult a healthcare professional before combining Sulbutiamine with any prescription medications, over-the-counter drugs, or other supplements.

Other namesYouvitan,, Arcalion,, Enerion,, Bisibuthiamine,
EffectsFocus, Memory, Anxiety Reducing